Journal Article

IMPULSE-2026-00009

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Commissioning, Characterization, and First High-Dose-Rate Irradiations at a Compact X-Ray Tube for Microbeam and Minibeam Radiation Therapy

Petrich, C. (Corresponding author)MLZ*TUM* ; Winter, J.MLZ*TUM* ; Dimroth, A.MLZ*FZJ* ; Stolz, J.MLZ*TUM* ; Beiser, T. ; Dehn, M. ; Frignani, J.TUM* ; Combs, S. E.TUM* ; Schilling, F. ; Natour, G. ; Aulenbacher, K. ; Raulefs, S.TUM* ; Schmid, T. E.TUM* ; Wilkens, J. J.TUM* ; Bartzsch, S.MLZ*TUM*

2026
Elsevier Science Amsterdam [u.a.]

Please use a persistent id in citations: doi:10.1016/j.ijrobp.2025.10.012

Abstract: PurposeMinibeam and microbeam radiation therapy promise improved treatment outcomes through reduced normal tissue toxicity at better tumor control rates. The lack of suitable compact radiation sources limits the clinical application of minibeams to superficial tumors and renders it impossible for microbeams. We developed and constructed the first prototype of a compact line-focus x-ray tube (LFXT) with technology potentially suitable for clinical translation of minibeams and microbeams.MethodsWe give an overview of the commissioning process preceding the first operation, present optical and radiological focal spot characterization methods, and dosimetric measurements. Additionally, we report on first preclinical in vitro cell and in vivo mouse brain irradiations conducted with the LFXT prototype.ResultsThe LFXT was high-voltage conditioned ≤300 kV. The focal spot characterization resulted in a strongly eccentric electron distribution with a width of 72.3 μm. Dosimetry showed sharp microbeam dose profiles with steep lateral penumbras and a peak-to-valley dose ratio above 10 throughout a 70-mm-thick polymethylmethacrylate (PMMA) phantom. An open-field dose rate of 4.3 Gy/s was measured at an acceleration voltage of 150 kV and a beam current of 17.4 mA at 150-mm distance from the focal spot. In vitro and in vivo experiments demonstrated the feasibility of the LFXT for minibeam and microbeam applications with field sizes of 1.5 to 2 cm. The mice displayed no observable side effects throughout the follow-up period after whole-brain 260-μm-minibeam irradiation.ConclusionWe successfully constructed and commissioned the first proof-of-concept LFXT prototype. Dosimetric characterizations of the achieved microbeam field showed the superiority of the LFXT compared with conventional x-ray tubes in terms of beam quality. In future developments, the remaining limitations of the prototype will be addressed, paving the way for improved minibeam and first ever microbeam radiation therapy in a clinical setting.

Keyword(s): Health and Life (1st) ; Biology (2nd) ; Instrument and Method Development (2nd) ; Medicine (2nd)

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Contributing Institute(s):

1. MICROFLASH (MICROFLASH)

Research Program(s):

1. DFG project G:(GEPRIS)459947066 - Analyse des Wirkmechanismus von Mikrostrahltherapie (MRT) auf Gliome in einem Mausmodell mittels innovativer 3D-Bildgebungstechnologie (459947066) (459947066)
2. DFG project G:(GEPRIS)416790481 - Tumortherapie mit Mikrostrahlen an kompakter Strahlenquelle (416790481) (416790481)

Experiment(s):

1. No specific instrument

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Database coverage:
; ; BIOSIS Previews ; BIOSIS Previews ; Biological Abstracts ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Ebsco Academic Search ; Essential Science Indicators ; Essential Science Indicators ; IF >= 5 ; IF >= 5 ; JCR ; JCR ; Nationallizenz ; Nationallizenz ; SCOPUS ; SCOPUS ; Science Citation Index Expanded ; Science Citation Index Expanded ; Web of Science Core Collection ; Web of Science Core Collection

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