Journal Article

IMPULSE-2024-00071

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pencil beam kernel-based dose calculations on CT data for a mixed neutron-gamma fission field applying tissue correction factors

Sommer, L. (Corresponding author)MLZ* ; Kampfer, S. ; Chemnitz, T.MLZ* ; Breitkreutz, H. ; Combs, S. E. ; Wilkens, J. J.

2024
IOP Publ. Bristol

Please use a persistent id in citations: doi:10.1088/1361-6560/ad209b

Abstract: Objective. For fast neutron therapy with mixed neutron and gamma radiation at the fission neutrontherapy facilityMEDAPPat the research reactorFRMII in Garching, no clinical dose calculationsoftware was available in the past. Here, we present a customized solution for research purposes toovercome this lack of three-dimensional dose calculation. Approach. The applied dose calculationmethod is based on two sets of decomposed pencil beam kernels for neutron and gamma radiation.The decomposition was performed using measured output factors and simulated depth dose curvesand beam profiles in water as reference medium. While measurements were performed by applyingthe two-chamber dosimetry method, simulated data was generated using the Monte Carlo codeMCNP. For the calculation of neutron dose deposition on CTdata, tissue-specific correction factorswere generated for soft tissue, bone, and lung tissue for theMEDAPPneutron spectrum. The pencilbeam calculations were evaluated with reference to Monte Carlo calculations regarding accuracy andtime efficiency. Main results. In water, dose distributions calculated using the pencil beam approachreproduced the input from Monte Carlo simulations. For heterogeneous media, an assessment of thetissue-specific correction factors with reference to Monte Carlo simulations for different tissueconfigurations showed promising results. Especially for scenarios where no lung tissue is present, thedose calculation could be highly improved by the applied correction method. Significance. With thepresented approach, time-efficient dose calculations on CT data and treatment plan evaluations forresearch purposes are now available for MEDAPP.

Keyword(s): Health and Life (1st) ; Medicine (2nd)

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Contributing Institute(s):

1. MEDAPP (MEDAPP)

Research Program(s):

1. GRK 2274 - GRK 2274: Fortgeschrittene Medizinische Physik für bildgeführte Krebstherapie (299102935) (299102935)

Experiment(s):

1. Medical Application Facility (SR10)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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