Journal Article

IMPULSE-2016-00085

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multifunctional Amphiphilic Nanoparticles Featuring (Bio)Degradable Core and Dual-Responsive Shell as Biomedical Platforms for Controlled Release

Gromadzki, D. (Corresponding author) ; Rychter, P. ; Uchman, M. ; Momekova, D. ; Marcinkowski, A. ; Koseva, N. S. ; El Fray, M. ; Marić, M.

2015
Wiley-VCH Weinheim

Please use a persistent id in citations: doi:10.1002/macp.201500235

Abstract: Multifunctional polymeric platforms combining (bio)degradable and biocompatible, temperature and pH-sensitive entities hold great promise as nanocarriers for targeted drug and gene delivery, and tissue engineering. In this work, preparation and characterization of surfactant-free polyester nanoparticles (NPs) from biobased polyesters poly(butylene sebacate) (PBSE) and poly(butylene sebacate-co-butylene dilinoleate)s (PBSE/PBDL) using nanoprecipitation is reported. This strategy leads to spherical nanosized particles with sizes narrowly distributed in a range of 30–200 nm which is appropriate for internalization by a variety of cells. The effect of molecular parameters and type of solvent used in the nanoprecipitation protocol on the size and shape of produced polyester nanocolloids and their in vitro degradation in PBS solution at 37 °C is elucidated by quasi-elastic light scattering (QELS), atomic force microscopy (AFM), transmission electron microscopy (TEM), and size-exclusion chromatography (SEC) techniques. A dense cationic brush layer (≈ 20 nm) of stimuli-responsive and biocompatible poly(2-dimethylaminoethyl methacrylate-co-acrylonitrile) is grafted on the surface of PBSE/PBDL NPs through “grafting onto” (arm first) coupling chemistry.

Keyword(s): Health and Life (1st) ; Health and Life (1st) ; Soft Condensed Matter (2nd)

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Contributing Institute(s):

1. KWS2

Experiment(s):

1. KWS-2: Small angle scattering diffractometer (NL3ao)

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Database coverage:
; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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